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Food appears to slightly increase and antacids appear to slightly decrease the absorption of famotidine, but these effects do not appear to be clinically important.
Unlike cimetidine, famotidine is considered to have little effect on the actions of other drugs such as warfarin, theophylline, phenytoin, diazepam, or procainamide.
Antacids may interact with other drugs such as propranolol, isoniazid, prednisolone, diflunisal, and naproxen which may cause formation of complexes that are not absorbed.
Antacids decrease the absorption of tetracycline and iron. Take tetracycline 1 hour before or 2 hours after antacids and 2 hours before or 3 hours after iron preparations and vitamin products that contain iron.
